Category Archives: Science & Technologies

Genetic diversity can prevent rapid spread of infectious diseases

Choice of pandemic: The models are best suited to study airborne diseases such as H1N1, say Nagasuma Chandra (left) and Narmada Sambataru.
Choice of pandemic: The models are best suited to study airborne diseases such as H1N1, say Nagasuma Chandra (left) and Narmada Sambataru.

The team studied how susceptibility sub-populations affect the spread of the disease

An infectious disease can spread at different rates in different countries. This phenomenon has been observed in many cases, for instance in the 2009 H1N1 influenza pandemic. An International group of researchers including those at Indian Institute of Science (IISc), Bengaluru, and The Institute of Mathematical Sciences (IMSc), Chennai, looks at genetics as a way to explain this phenomenon. They find that the greater the genetic diversity in immune response, the stronger is the barrier to the spread of the disease. The results have recently been published in PLOS Computational Biology.

Nagasuma Chandra’s team at IISc chose to study H1N1 as modelling it had some advantages.

“There is a lot of work on H1N1 and a lot of data including clinical and epidemiological. These models are also best suited to study airborne diseases. As H1N1 spreads through air, choosing it made a lot of sense,” says Dr. Chandra.

Pandemic H1N1 virus

The pandemic H1N1 2009 influenza A virus was different from other influenza viruses encountered until then. According to the WHO, this is because it originated from animal influenza viruses and is unrelated to the human seasonal H1N1 viruses that have been in circulation among people formany years In fact, this virus is thought to have arisen from a mixture of two viruses: a North American virus that jumped from birds to swine and humans and a Eurasian swine virus that had circulated in pigs for about a decade before entering humans. Clinically also the virus’s effect was very different from that of other flu viruses in that younger people were more severely affected than older ones.

Narmada Sambataru and Sumanta Mukherjee who were at Dr Chandra’s lab, and Martin Lopez-Garcia from the University of Leeds, UK, spent nearly a year building up the model. Their research led them to establish how an individual’s genetic makeup can influence his or her susceptibility to the infection.

The immune system has both innate and adaptive response types to infections, in general. In the case of H1N1 infection, the adaptive immune system can recognise the presence of a virus within the cell and respond to it only if a molecule called the human leukocyte antigen (HLA) binds to some fragment of the viral protein (epitope) and ‘presents’ it to the environment outside the cell. Dr Chandra’s group has described the details of this aspect of H1N1 in an earlier paper published in the journal Clinical and Translational Immunology.

Immune response

“The main take-away from our work is that understanding how the immune response of different individuals leads to a spread of susceptibilities in a population is vital to figuring out how diseases spread,” says Gautam Menon of The Institute of Mathematical Sciences, a co-author of the paper. “This problem, of how to go from what we know about how individuals can vary in their susceptibility to understanding how epidemics spread across entire populations, has been identified recently as one of the major challenges in the study of epidemics.”

Having worked out how the genetic makeup of an individual can affect their susceptibility to the disease, the individuals can be grouped according to their susceptibility. Using a mathematical model called the SIR (Susceptible-Infected-Recovered) model, the researchers study how the presence of susceptibility sub-populations affect the spread of the disease. “In this model, individuals are initially susceptible but not infected.

“When an infection is introduced, individuals become infected at a rate determined by their estimated susceptibility to the pathogen, estimated using genetic information about the host as well as the pathogen. Infected individuals then proceed to recover,” says Dr Chandra.

Trends

The work captures the qualitative features of well-known trends of influenza spread in various parts of the world. “This work uses publicly available information about HLA class-I genes and their prevalence in populations around the world. Unfortunately, there is a significant shortage of this information for Indian populations,” she says.

The group is planning to propose a detailed study of this for Indian populations. “Once this information becomes available, we can do far more to predict disease spread in India. These predictions can be used to inform public policy and make better decisions. This is the real utility of such modeling methods, that we can explore different situations and ask what responses might be most effective in the context of specific diseases,” says Dr Menon.

source: http://www.thehindu.com / The Hindu / Home> Science / by Subashree Desikan / March 31st, 2018

Community fridge at Kandanchavadi

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The initiative is driven by a software company

Prodapt, a software and engineering services provider, has set up a community refrigerator at Prince Infocity II on Rajiv Gandhi Salai in Kandanchavadi. The company has an office at this IT facility.

Employees of Prodapt and other companies at Infocity II can stock the refrigerator with food, fruits, sweets and savouries.

The refrigerator will be kept open from 7 a.m. to 9 p.m, all through the week.

This initiative of Prodapt is supported by Ayyamittu Unn, launched by The Public Foundation last year.

Mary Vikram, who is part of the human resources department at Prodapt, says, “We will ensure there is no lack of food in the refrigerator, between 7 a.m. and 9 p.m. If necessary, Prodapt will buy food from nearby restaurants and food courts and keep the refrigerator well-stocked. Though the refrigerator is located on the premises of Prince Infocity II, a separate entrance has been created to enable access to it. This way, the movement of employees will not be hampered.

Prodapt has employed a security guard to manage the beneficiaries queuing up in front of the refrigerator. He also has to ensure that nobody takes more than their fair share of food. As there is always the possibility that some beneficiaries will sell the food.”

Uncooked grains, pulses and vegetables and raw meat, fish and eggs are a strict no-no. Vegetables that make up a salad are an exception though. Any food found bitten will not be accepted. Donors will not be allowed to keep the food in vessels. They have to pack the food before placing it in the refrigerator. The packed food should have a label providing information such as name of the cuisine, the time it was cooked and the probably time it can go stale.

A logbook containing the names of donors, their contact numbers, the food items they have donated, the time these items was cooked, and how long they will last, will be maintained.

Similarly, a record of the names and contact details of the beneficiaries and what they took will also be maintained.

Issa Fathima Jasmine, founder of The Public Foundation, says “As construction work is high on Rajiv Gandhi Salai, there are many daily wage labourers, including migrant workers, in the region. They will benefit from this initiative. And the IT professionals can be donors.”

The customised refrigerator has also been provided with slots with normal temperature where people can leave clothes, books and stationeries.

For details, call 94451 97723 / 94451 97728.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Chennai / by L. Kanthimathi / March 30th, 2018

Insect Museum opened at TNAU

Under the theme ‘Bugs Are Kings’, the museum displays insects as preserved specimens and models on their behaviour, habits and habitat.

Chief Minister Edappadi K. Palaniswami opened an insect museum in Tamil Nadu Agricultural University (TNAU) on Monday. First of its kind established at the Department of Agricultural Entomology of TNAU, the museum houses 20,000 insects from 50 species.

Inaugurating the museum, Mr. Palaniswami said that the research and expertise which helped to realise the facility will be beneficial to farmers, researchers, students and the public.

“Haling from agricultural background, I have seen farmers worrying over insects affecting various crops. The museum will help farmers to gain more knowledge about insects, those helpful and harmful to farming,” said Mr. Palaniswami.

Speaking at the event, Minister for Agriculture R. Doraikkannu pointed that insects were causing about 20 % crop loss in the State and the museum will be beneficial for farmers.

Established at a cost of ₹ 5 crore, the museum displays insects as preserved specimens, live specimens depicting their life cycle, images, videos and models on their behaviour, habits and habitat under the theme ‘Bugs Are Kings’.

Right wall of the exhibit area of 6,691 sqft covers insects under five sections namely insect diversity, insect biology, beneficial insects, insect and plants, and cultural entomology. The left wall of the museum displays curated specimens of 27 insect orders along with their charts. Videos related to insects are played through television on the walls. Three touch screen gadgets with information on insect trivia, insect records and insects around you are also kept at the museum.

Physically challenged persons can access the museum through a ramp. Financed by the Government of Tamil Nadu, the museum has electronic ticketing facility for visitors.

Minister for Forest Dindigul C. Sreenivasan, Minister of Municipal Administration and Rural Development S. P. Velumani, Deputy Speaker Pollachi V. Jayaraman, Agricultural Production Commissioner and Principal Secretary to Government Gagandeep Singh Bedi, District Collector T.N. Hariharan, and TNAU Vice-chancellor K. Ramasamy were present at the inaugration.

source: http://www.thehindu.com / The Hindu / Home> News> States / by Staff Reporter / Coimbatore – March 26th, 2018

Doctors of Royapettah Hospital bring out a book on toxicology

ToxicologyMPOs26mar2018

Doctors of the Department of Internal Medicine at Government Royapettah Hospital have brought out a book, Manual of Toxicology — An Indian Perspective, which, they say, will fill a lacunae in the knowledge about poisons.

“Most toxicology manuals are silent on many of the Indian posions, as they have been written from a western perspective. This book is based on our experience treating cases involving toxins,” says Dr. A. Shaik Sulaiman Meeran, one of the doctors who spearheaded this book project.

Dr. P. Paranthaman was the editor-in-chief. Dr. Sulaiman, Dr. A. Samuel Dinesh and Dr. D. Venkateswaralu served as associate editors and Dr. P. Raja as co-editor. The book has been brought out by Chess Educational Publishers.

Dr. Sulaiman says that knowing the sources of danger will prevent accidental ingesting of poisons or strikes by venomous reptiles and insects.

Knowing where to seek help will be a crucial factor in recovery.

He says snake bite cases from the southern suburbs, which include Tambaram and surrounding areas, parts of Old Mahabalipuram Road and East Coast Road are common. Anti-venom serum for treatment of bites by cobra, viper and krait is available. Government general hospitals have them.

Residents of semi-urban areas can face the problem of snake bikes, it is available in primary health centres, he says. Here is a word of caution. “Ninety percent of the sea snakes are poisonous and there is no anti-venom serum for them. Only supportive treatment can be given. Sea snakes are sometimes found near fishermen’s settlements. They get entangled in fishermen’s nets and are brought ashore. There is always a high possibility of finding them near fishermen’s hamlets on East Coast Road,” says Dr. Sulaiman.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Chennai / March 23rd, 2018

IIT-M ties up with Australian varsity for research in metallurgy

Culmination of work by several people, says Australian Minister

The Indian Institute of Technology – Madras has tied up with the Deakin University of Australia to conduct research in metallurgy and manufacturing materials.

The Centre of Excellence in advanced materials and manufacturing was officially inaugurated on Wednesday by Philip Dalidakis, Minister for Trade and Innovation, Victoria. The partnership with Deakin University happened because of the vision of a group of people. “In 1994, Deakin University reached out to the Indian market. It was the first Australian university to come to India. Today is the culmination of a lot of work by a lot of people,” Mr. Dalidakis said.

The association with Deakin University was the oldest and most developed one, said IIT-M director Bhaskar Ramamurthi. The institute was keen that the centre take forward the relationship to research and development by including the industry and introduce “some really good innovation” that would reach the public.

The centre was housed in the research park “to constantly remind ourselves that the main goal is to achieve the outward thrust toward industry in the form of product and innovation start up,” Mr. Ramamurthi said.

B.S. Murty, professor at the Department of Metallurgical and Materials Engineering at the institute, said the aim was not only to collaborate and have a tripartite programme and work with industry, but also to conduct joint doctoral and masters programmes.

Youngsters would be trained in materials manufacturing and metallurgy and the centre would also sponsor internships. Already, an alumna had offered to sponsor 10 students for internship at the IIT-M, especially from smaller universities in and around the city, he said.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Chennai / by Special Correspondent / Chennai – March 15th, 2018

The sidelined goddess of Botany

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The first Indian woman botanist, E K Janaki Ammal, ought to be more widely known for her huge contributions to science. But she remains unknown within the country and outside academic circles and even our textbooks have failed to teach our children about her glorious scientific history

: Just a fortnight before the International Women’s Day, the John Innes Centre in Norfolk, UK, announced a new scholarship for post-graduate students from developing countries in honour of an Indian woman botanist. Under the scheme, 88 applicants who wish to study plant and microbial sciences can apply in commemoration of the distinguished work and contributions of Dr.E.K.Janaki Ammal who was an international alumni of the leading research and training centre between 1940 and 1945.

A heart warming gesture from an institution abroad, but may be India should have done something similar for the country’s first home grown woman scientist, who went overseas and returned accomplished breaking every caste and gender barrier through her work.

Just take a moment to think where we would be without the inventions of this brilliant mind.

Janaki Ammal in younger days | Photo Credit: Special Arrangement
Janaki Ammal in younger days | Photo Credit: Special Arrangement

After laborious crossbreedings in the laboratory of Sugarcane Breeding Institute in Coimbatore in the 1930s, she created the indigenous variety of sweetened sugarcane that we consume today. Till then India was producing sugarcane in abundance and yet importing as they were not as sweet as the ones grown in the Far East.

During the World War II bombings in the 1940s, she continued her phenomenal research into chromosomes of thousands of species of flowering plants at the John Innes Horticultural Institute, Norfolk, where she worked with some of the best names in cytology, genetics and botany While working on the gorgeous Magnolia, she co-authored The Chromosome Atlas of Cultivated Plants with renowned biologist CD Darlington.

The magnolia saplings she planted on the Battleston Hill in Wisley continue to bloom every Spring and one of the pure white blooms is named after her, the Magnolia kobus Janaki Ammal and apparently only few nurseries in Europe have the variety today.

At a time when most Indian women did not even attend school, she received scholarship and obtained her MS from University of Michigan in 1925 and later returned as the first Indian Oriental Barbour Fellow. She remains one of the few Asian women to be conferred honorary doctorate (DSc. honoris causa) by her alma mater in 1931. There she discovered a new variety of brinjal that exhibited triploidy instead of the normal diploid, where there are two sets of chromosomes in the cells.

The flower Magnolia Kobus Janaki Ammal | Photo Credit: Special Arrangement
The flower Magnolia Kobus Janaki Ammal | Photo Credit: Special Arrangement

At the insistence of Prime Minister Jawaharlal Nehru, she returned to India in the 1950s and restructured the Botanical Society of India travelling to several remote areas of the country in search of the plant lore of the indigenous people and scouting for medicinal plants in her home State, Kerala.

A fascinating figure of the early 20th Century she was. E.K.Janaki Ammal lived a life which perhaps very few women of her time could dream of. The distinguished geneticist, cytologist, global plant geographer studied about ecology and biodiversity too and did not fear to take on the Government as an ardent environmental activist. She played an important role in the protests against the building of a hydro-power dam in Kerala’s Silent Valley in the 1970s. She made a mark with her paper on “Man’s Role in Changing the Face of the Earth” at an international symposium in Princeton in 1955 and two decades later, she was awarded the Padmashri in 1977.

With a profile like hers, Janaki Ammal never got into spotlight. If anything she fought her status as a single woman from a caste considered backward and problems with male mentorship in her field. But she proved through her work that Science knows no caste, gender or social boundaries.

Yet for her extraordinary journey from small town Thalassery to the finest institutions across the world, there is no archive related to her in India. Her papers are available only in hard copy at the Bodleian Library in Oxford, according to Vinita Damodaran, who teaches South Asian History at University of Sussex and has also published a well researched paper on “Gender, race and science in twentieth century India: E.K.Janaki Ammal and the history of science.”

Luckily, the Nikari series of talks held under the banner of ‘Manarkeni’, a Tamil research journal, brings to light the works of lesser known women in different fields. In the previous years, the focus was on women in literature and history. This year it chose science and brought the story of Janaki Ammal to the fore.

The talk delivered by S Krishnaswamy, former professor at the School of Biotechnology, Madurai Kamaraj University, highlighted various stages of Janaki’s career both in India and overseas. “Her career shows that scientists must speak their mind with social consciousness even if it means going against the policies of the government. In today’s context, it becomes necessary to bring achievers like her to the forefront,” he asserts.

Janaki Ammal must have conquered her fears and broke the glass ceiling for a rewarding career in science. “She wanted to be known only through her work. Let her work be known to all successive generations, who have much better opportunities” says Krishnaswamy.

An inspiring role model, Janaki Ammal passed away in 1984 at the age of 87 at Maduravoyal near Chennai, while working in the field laboratory of the Centre for Advanced Study in Botany, Univerity of Madras. She perhaps did not receive the acclaim she deserved but devoted herself to research, opening up a universe of possibilities. Let our children not be bereft of that knowledge. It is worth knowing and remembering leaders in science like Janaki Ammal.

source: http://www.thehindu.com / The Hindu / Home> Society / by Soma Basu / Madurai – March 09th, 2018

Supercapacitor built from discarded lithium ion batteries

Efficiency: Lithium-ion batteries used widely are disposed, leading to mounting e-waste. Our method helps reuse these, says Subrata Kundu (right).
Efficiency: Lithium-ion batteries used widely are disposed, leading to mounting e-waste. Our method helps reuse these, says Subrata Kundu (right).

Graphene oxide from old batteries was used

Used old batteries can now help create supercapacitors, which can in turn create better long-lasting batteries.

Scientists from CSIR–Central Electrochemical Research Institute (CSIR-CECRI) in Karaikudi, Tamilnadu, and CSIR–Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI) in Bhavnagar, Gujarat, collected discarded lithium-ion batteries and created reduced graphene oxide from them. This new material showed high specific capacity at low current making it an ideal material for next generation high-performance supercapacitor.

“The specific capacity was found to be 112 farad per gram from fundamental evaluation, which is almost equal to the commercially available ones. Also the ones available in market today are created using activated carbon which is expensive and environmentally hazardous while our method is cheaper and fully environmental friendly” explains by Sivasankara Rao Ede, Ph.D scholar from CSIR-CECRI and one of the first authors of the paper published in Colloids and Surfaces A: Physicochemical and Engineering Aspects.

The new electrodes made using the reduced graphene oxide showed high stability even after 20,000 cycles. They also had high retention capacity where 70% of the efficiency was retained even after 85 cycles. The efficiency slowly increased and reached 108% after 20,000 cycles. The long-term stability and robustness of the capacitor are the key parameters for qualifying as suitable candidates for commercial application.

“Today lithium-ion batteries are used widely and disposed after they run out, leading to mounting e-waste. We tried a new method and succeeded in recycling and reusing these batteries,” says Dr Subrata Kundu, from CSIR-CECRI and one of the corresponding authors.

The graphite anode and aluminium and stainless steel from dismantled batteries were used. The graphite was converted into graphene oxide by oxidation and subsequent exfoliation. Graphene oxide was further reduced to reduced graphene oxide.

Supercapacitors are now being used explicitly in wind turbine pitch control, rail (on-board or wayside), automotive (including hybrid vehicles), heavy industrial equipment, UPS and Telecom systems for power delivery and memory backup. “We are further evaluating the capacitive nature of our prepared electrode in two electrode system and hope to bring it out soon for large scale commercial applications,” says H. C. Bajaj, emeritus scientist at CSIR-CSMCRI and the other corresponding author.

source: http://www.thehindu.com / The Hindu / Home> Science / by Aswathi Pacha / March 03rd, 2018

Two T.N. students’ artwork finds place in NASA calendar

NASA had received about 3,000 entries from 193 countries

Two students from Shree Vidhya Mandhir, Pushpathur, Dindigul district won the NASA’s 2018 Commercial Crew Program Calendar Art Contest.

The artworks of students Kaviya B.J. and K. Selva Sreejith of Class VI were among the 12 selected from about 3,000 entries submitted by children in the age group of 4-12 years from 193 countries. Their work will be printed in the 2018 calendar of NASA will be sent to the International Space Station.

While Kaviya drew an organic space garden, Sreejit’s artwork was titled ‘What would you take from home’, where he drew an astronaut who brought along his daughter, dog and all his favourite possessions to the space shuttle. The winning students will receive a gift package from NASA. The students were able to participate in the contest because of a tie-up between the school and Imageminds, a digital media training centre.

source: http://www.thehindu.com / The Hindu / Home> News> Cities / by Staff Reporter / Chennai – January 17th, 2018

City gets first drive-in blood collection centre

Centre will largely benefit senior citizens and the physically-challenged

Two years after shedding his stake in Metropolis Healthcare Limited, G.S.K.Velu is busy with his next healthcare venture — Neuberg Diagnostics — and has opened Chennai’s first drive-in Phlebotomy (blood collection) centre.

“Neuberg Ehrlich has opened the first drive-in blood collection centre,” the healthcare entrepreneur told The Hindu.

According to Mr. Velu, chairman, Neuberg Diagnostics, the drive-in blood collection centre will provide ease, especially for senior citizens and the physically challenged, for quick blood collection even without getting out of the car. If possible, they could briefly get out and give the blood in the drive-in area itself without even getting into the laboratory and waiting in queue. All testing requests can be made through the phone and the validated results can be obtained through the internet.

Quick testing

“The entire process can be done in seven minutes and if there is a pre-booking it can be done within three to four minutes and by pre-booking one can save on registration time,” he said.

Mr. Velu said that the equipment were specially designed to collect samples.

Neuberg Ehrlich currently has eight centres in Chennai, and the group intends to open 25 centres in the next one year. It also has operations in the UAE, South Africa and Sri Lanka, and carries out over 16 million tests per annum.

Ehrlich Laboratory, accredited by NABL, Government of India and CAP (College of American Pathologist, USA) was recently renamed as Neuberg Ehrlich after it became a part of Neuberg Diagnostics Group.

source: http://www.thehindu.com / The Hindu / Home> News> Cities> Chennai / by Staff Reporter / Chennai – December 16th, 2017

Lifesaver: Chennai doctors plan second heart in tummy

LUBDUB : Surgeons have successfully placed a heart in the dog's tummy
LUBDUB : Surgeons have successfully placed a heart in the dog’s tummy

______________________________

HIGHLIGHTS

  • Heterotropic abdominal heart transplants or piggyback transplant uses discarded hearts of terminally ill patients
  • The new heart placed in the abdomen doesn’t replace the original heart, but supports it in performing its job
  • The technology can be a substitute for expensive heart assistive devices and pumps
  • __________________________

Chennai :

Soon, patients seeking a heart transplant could be left with two— including one in the tummy. City-based cardiac surgeons have put an extra heart in the tummy of two dogs to see if it could help those with a weak heart survive. The answer was yes.

A Frontier Lifeline team has sought the state transplant authority’s permission to retrieve ‘misfit’ hearts from donors for ‘piggyback transplants’ in patients not fit for a full-fledged heart transplant.

On Tuesday, when a few heart transplant surgeons presented their experiment to other heart surgeons and Transtan officials, they admitted they would have to do larger human trials to see if it will be successful. “We will be forwarding the recommendation to the government,” said Transtan member secretary Dr P Balaji.

Surgeons discard donor hearts if their pumping capacity is below 30%. On the contrary, many patients with heart failure may not be able to go in for transplants because of multi-organ failure or other complications, said Frontier Lifeline chief Dr K M Cherian. Such patients will require a left ventricular assist device, a mechanical pump implanted inside the s chest to help a weak heart pump blood. “That machine costs up to Rs 1 crore, he said.

Dr Cherian said, “Instead if we give them an additional heart that is marginally functioning, itcan save money and life,” Doctors call this ‘bio-left ventricular assist device.’ Earlier this year, doctors in Coimbatore did heterotropic heart transplants, where they left an additional smaller heart in the chest cavity of a patient. Doctors say by leaving the heart in the abdomen — and thereby avoiding cutting open the chest — they can reduce surgical risk by several times.
Heterotropic abdominal heart transplants,leave the patient’s existing organ in place unlike a heart transplant. The new heart doesn’t replace the heart but helps it do its job. “It can be a bridge to transplant until the patients get fit, or it can just be the treatment required,” said heart-and-lung transplant surgeon Dr Madhu Shankar of Frontier Lifeline.

During the animal experiment, doctors connected the donor heart to abdominal portion of the aorta and other major blood vessels in the abdomen. “In dogs, we found that thisheart worked as ‘assistant’ to the existing heart. While one of them died on the first day because it did not have adequate amount of donor blood, theother was alive for 48hours walking and taking feed,” said Dr Madhu Shankar. Tests and scans done on the animal showed that the second heart was pumping with efficient cardiac output.

Postmortem on the two dogs showed that their heart muscle was viable. “It indicates the success of the transplant,” said Dr Shankar. The hospital has now sought permission from the ethics committee for clinical trial. “It may take some time before it this becomes a bedside therapy, but we should make a beginning.”

source: http://www.timesofindia.indiatimes.com / The Times of India / News> City News> Chennai News / by Pushpa Narayan / TNN / December 11th, 2017